Jinan Xinke Pharma Science and Technology Co.,Ltd.

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Profile: Jinan Xinke Pharma Science and Technology Co.,Ltd. specializes in researching, manufacturing and marketing of value added APIs (active pharmaceutical ingredients) and their intermediates. Tenofovir alafenamide base is a key intermediate of the synthesis of tenofovir alafenamide fumarate. Roxadustat is an API of the drug to treat anemia.

11 Products/Chemicals (Click for related suppliers)

• AKR 501

IUPAC Name: 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid | CAS Registry Number: 570406-98-3
Synonyms: AVATROMBOPAG, AKR-501, E5501, Avatrombopag [USAN], UNII-3H8GSZ4SQL, Avatrombopag (USAN/INN), CHEMBL2103883, YM477, DCL000686, YM 477, AS 1670542, D10306, E 5501, 4-Piperidinecarboxylic acid, 1-(3-chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-

Molecular Formula:	C₂₉H₃₄Cl₂N₆O₃S₂	Molecular Weight:	649.654660 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	10

InChIKey: OFZJKCQENFPZBH-UHFFFAOYSA-N

• Axitinib

IUPAC Name: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide | CAS Registry Number: 319460-85-0
Synonyms: Axitinib [USAN], AG-013736, CID6450551, AG-13736, AG 013736, Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazo)-6-yl)thio)-, N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, 790713-39-2

Molecular Formula:	C₂₂H₁₈N₄OS	Molecular Weight:	386.469520 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	4

InChIKey: RITAVMQDGBJQJZ-FMIVXFBMSA-N

• Benzamide, 2-Mercapto-N-Methyl-

IUPAC Name: N-methyl-2-sulfanylbenzamide | CAS Registry Number: 20054-45-9
Synonyms: 2-MERCAPTO-N-METHYLBENZAMIDE, N-methyl-2-sulfanylbenzamide, AC1NBZ0P, SureCN2829218, CTK8D3874, Benzamide, 2-mercapto-N-methyl-, AKOS000196042, KB-24825, AM20090683, FT-0690189

Molecular Formula:	C₈H₉NOS	Molecular Weight:	167.228160 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	2

InChIKey: VIFOAZNEQRHREM-UHFFFAOYSA-N

• FG-4592 intermediate

IUPAC Name: methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate | CAS Registry Number: 1455091-10-7
Synonyms: Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate, SCHEMBL15268823, YTWDBRIDKWWANA-UHFFFAOYSA-N, AKOS027461061, ZINC146746245, 4-Hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

Molecular Formula:	C₁₇H₁₃NO₄	Molecular Weight:	295.294 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	5

InChIKey: YTWDBRIDKWWANA-UHFFFAOYSA-N

• GS-7340

IUPAC Name: propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate | CAS Registry Number: 379270-37-8
Synonyms: TENOFOVIR ALAFENAMIDE, UNII-EL9943AG5J, Tenofovir Alafenamide [USAN], GS 7340, 377091-31-1, L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester

Molecular Formula:	C₂₁H₂₉N₆O₅P	Molecular Weight:	476.465922 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	10

InChIKey: LDEKQSIMHVQZJK-LYTUVDLCSA-N

• N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]Glycine

IUPAC Name: 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid | CAS Registry Number: 808118-40-3
Synonyms: FG-4592, CHEMBL2338329, N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine, Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-, n-((4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl)glycine, (((4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl)amino)acetic acid, [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic Acid, PubChem24327, SureCN523705, UNII-X3O30D9YMX, cc-211, AGN-PC-005EN5, CTK2I7260, MolPort-021-804-955, BCPP000230, FG-4592,ASP1517, BCP9000684, CS-1094, FG 4592, QC-7436

Molecular Formula:	C₁₉H₁₆N₂O₅	Molecular Weight:	352.340740 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	6

InChIKey: YOZBGTLTNGAVFU-UHFFFAOYSA-N

• Phosphonic acid,[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monophenylester

IUPAC Name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphinic acid | CAS Registry Number: 379270-35-6
Synonyms: (R)-Phenyl hydrogen (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate, SCHEMBL13155602, AKOS030528681, CS-W004381, HE339639, phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate, PHOSPHONIC ACID,[[(1R)-2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL]-, MONOPHENYLESTER

Molecular Formula:	C₁₅H₁₈N₅O₄P	Molecular Weight:	363.314 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	8

InChIKey: ITAMCOCNZJPJDF-LLVKDONJSA-N

• Tenofovir Alafenamide Fumarate

IUPAC Name: (E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate | CAS Registry Number: 1392275-56-7
Synonyms: Tenofovir Alafenamide fumarate, UNII-FWF6Q91TZO, Tenofovir Alafenamide fumarate [USAN], GS-7340-03, 1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate, (2E)-2-butenedioate, L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)

Molecular Formula:	C₄₆H₆₂N₁₂O₁₄P₂	Molecular Weight:	1069.004004 [g/mol]
H-Bond Donor:	6	H-Bond Acceptor:	24

InChIKey: SVUJNSGGPUCLQZ-ZFNQIRAGSA-N

• Tenofovir alafenamide hemifumarate

Molecular Formula:	C₄₆H₆₂N₁₂O₁₄P₂	Molecular Weight:	1069.004004 [g/mol]
H-Bond Donor:	6	H-Bond Acceptor:	24

InChIKey: SVUJNSGGPUCLQZ-ZFNQIRAGSA-N

• 4-Piperidinecarboxylic acid,1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-, (2Z)-2-butenedioate (1:1)

IUPAC Name: (Z)-but-2-enedioic acid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid | CAS Registry Number: 677007-74-8
Synonyms: Avatrombopag maleate, E5501 MALEATE, Avatrombopag maleate (USAN), Avatrombopag maleate [USAN], AKR-501 monomaleate, UNII-GDW7M2P1IS, CHEMBL2105758, YM-477, D10307, E-5501, 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2- yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid mono-(2Z)-but-2-enedioate, 4-Piperidinecarboxylic acid, 1-(3-chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1- piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-, (2Z)-2-butenedioate (1:1)

Molecular Formula:	C₃₃H₃₈Cl₂N₆O₇S₂	Molecular Weight:	765.726820 [g/mol]
H-Bond Donor:	4	H-Bond Acceptor:	14

InChIKey: MISPBGHDNZYFNM-BTJKTKAUSA-N

• 1H-Indazole, 3-iodo-6-nitro-

IUPAC Name: 3-iodo-6-nitro-2H-indazole | CAS Registry Number: 70315-70-7
Synonyms: 3-IODO-6-NITRO-1H-INDAZOLE, 3-Iodo-6-nitroindazole, 3-Iodo-6-nitro (1H)indazole, AG-G-74572, 1H-INDAZOLE, 3-IODO-6-NITRO-, SureCN1176140, KSC494C8F, CTK3J4182, ANW-48568, AR2396, WTI-10355, ZINC14983610, AKOS015898568, PB32533, RP08967, AK-79336, BR-79336, KB-32299, WT-131127, A9280

Molecular Formula:	C₇H₄IN₃O₂	Molecular Weight:	289.030030 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: GZCGNGLOCQEDMT-UHFFFAOYSA-N