Hangzhou Tino Bio-Tech Co., Ltd.

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Profile: Hangzhou Tino Bio-Tech Co., Ltd. specializes in the production of APIs, pharmaceutical intermediates, pesticide intermediates and special chemical reagents. Our active pharmaceutical ingredients include delavirdine, darunavir, indinavir, amprenavir and fosamprenavir calcium. Our pharmaceutical intermediates include dimethyl malate, 3-hydroxytetrahydrofuran, (1S,2S)-(1-benzyl-3-chloro-2-hydroxypropyl)carbamic acid tert-butyl ester, N-[3(S)-benzyloxycarbonylamino-2-(R)-hydroxy-4-phenyl]-N-isobutylamine and (2S,3S)-1,2-epoxy-3-(Cbz-amino)-4-phenylbutane. Our chiral auxiliaries include (1R,2S)-(-)-2-amino-1,2-diphenylethanol, (S)-(-)-2-amino-3-methyl-1,1-diphenyl-1-butanol, (S)-alpha,alpha-bis(4-methoxyphenyl)-2-pyrrolidinemethanol, (R)-alpha,alpha-bis(4-methylphenyl)-2-pyrrolidinemethanol, (R)-4-boc-piperazine-3-carboxylic acid and (2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine. (1R,2S)-(-)-2-amino-1,2-diphenylethanol is a white crystalline powder used as chiral ligand. Delavirdine is a crystalline solid.

14 Products/Chemicals (Click for related suppliers)

• Active Pharmaceutical Substances

• Amprenavir

IUPAC Name: [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate | CAS Registry Number: 161814-49-9
Synonyms: amprenavir, Agenerase, Prozei, Vertex, Vertex VX478, 1hpv, Amprenavir [USAN], Agenerase (TM), Agenerase (TN), GNA & Amprenavir, HHA & Amprenavir, 1t7j, VX-478, VX 478, HSDB 7157, Amprenavir (JAN/USAN/INN), DRG-0258, C25H35N3O6S, CHEBI:40050, KVX-478

Molecular Formula:	C₂₅H₃₅N₃O₆S	Molecular Weight:	505.626900 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	8

InChIKey: YMARZQAQMVYCKC-OEMFJLHTSA-N

• Darunavir

IUPAC Name: [(3R,3aS,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate | CAS Registry Number: 206361-99-1
Synonyms: Prezista, Darunavirum, 2idw, 2ien, Darunavir [USAN], TMC-114, Darunavirum [INN-Latin], TMC114, 2f8g, 2hs1, 2hs2, Darunavir (USAN/INN), UIC-94017, TMC 114, AIDS073035, UNII-YO603Y8113, 2f80, 2f81, AIDS-073035, CID213039

Molecular Formula:	C₂₇H₃₇N₃O₇S	Molecular Weight:	547.663580 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	9

InChIKey: CJBJHOAVZSMMDJ-HEXNFIEUSA-N

• Delavirdine

IUPAC Name: N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide | CAS Registry Number: 136817-59-9
Synonyms: Rescriptor, Rescriptor (TM), BHAP der, Delavirdine [INN], UNII-DOL5F9JD3E, BHAP-U 90152, Delavirdine (*Mesylate salt*), C22H28N6O3S, CID5625, U90152S (*Mesylate salt*), AIDS005059, AIDS086776, 147221-93-0 (mesylate), AIDS-005059, AIDS-086776, PNU-90152-T, ZINC18516586, Delavirdine(U-90152) & .a.IFN, U-90152S, u-90152

Molecular Formula:	C₂₂H₂₈N₆O₃S	Molecular Weight:	456.561120 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	7

InChIKey: WHBIGIKBNXZKFE-UHFFFAOYSA-N

• Dimethyl Malate

IUPAC Name: dimethyl (2S)-2-hydroxybutanedioate | CAS Registry Number: 617-55-0
Synonyms: Dimethyl (S)-(-)-malate, Dimethyl L-malate, L-(-)-Malic Acid Dimethyl Ester, Dimethyl (S)-2-hydroxysuccinate, PubChem6778, Dimethyl L-(-)-Malate, AC1Q41UI, 374318_ALDRICH, 02315_FLUKA, MolPort-001-790-894, MolPort-001-791-664, L-(-)-Apple Acid Dimethyl Ester, ANW-50550, ZINC02031458, AKOS015850984, AG-G-25342, RP22482, AK-50385, BR-50385, 1,4-dimethyl (2S)-2-hydroxybutanedioate

Molecular Formula:	C₆H₁₀O₅	Molecular Weight:	162.140600 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	5

InChIKey: YSEKNCXYRGKTBJ-BYPYZUCNSA-N

• Fosamprenavir Calcium

IUPAC Name: calcium [(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenylbutan-2-yl] phosphate | CAS Registry Number: 226700-81-8
Synonyms: Lexiva, Fosamprenavir calcium, Telzir, Lexiva (TN), Amprenavir phosphate calcium, Fosamprenavir calcium [USAN], Fosamprenavir calcium (USAN), GW433908G, CID131535, VX-175, GW-433908G, GW-433908, LS-186584, D03835, ((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-benzyl-2-(phosphonooxy)propyl)carboxamide calcium salt, Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, C-((3S)-tetrahydro-3-furanyl) ester, calcium salt, (3S)-Tetrahydro-3-furyl ((alphaS)-alpha-((1R)-1-hydroxy-2-(N(sup 1)-isobutylsulfanilamido)ethyl)phenethyl)carbamate, calcium phosphate (ester) (1:1), Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, C-((3S)-tetrahydro-3-furanyl) ester, calcium salt (1:1)

Molecular Formula:	C₂₅H₃₄CaN₃O₉PS	Molecular Weight:	623.668921 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	11

InChIKey: PMDQGYMGQKTCSX-HQROKSDRSA-L

• N,N'-Disuccinimidyl carbonate

IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) carbonate | CAS Registry Number: 74124-79-1
Synonyms: Di(succinimido) carbonate, N-Succinimidyl carbonate, Di(N-succinimidyl) carbonate, 225827_ALDRICH, carbonic acid disuccinimido ester, 43720_FLUKA, EINECS 277-730-3, CID676246, SBB005976, TL8006647, DSC

Molecular Formula:	C₉H₈N₂O₇	Molecular Weight:	256.169020 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	7

InChIKey: PFYXSUNOLOJMDX-UHFFFAOYSA-N

• Pharmaceutical Actives

• Sodium Valproate

IUPAC Name: sodium 2-propylpentanoate | CAS Registry Number: 1069-66-5
Synonyms: Sodium valproate, Valproate sodium, Depakene, Epilim, Convulex, Eurekene, Labazene, Orfiril, Valerin, Natrium valproat, Selenica, Sodium 2-propylpentanoate, Valproic acid sodium salt, Dipropylacetate sodium, Sodium dipropylacetate, Depakene (TN), Selenica (TN), Sodium bispropylacetate, Valproic acid sodium, Valproinsaeure, natrium

Molecular Formula:	C₈H₁₅NaO₂	Molecular Weight:	166.193270 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	2

InChIKey: AEQFSUDEHCCHBT-UHFFFAOYSA-M

• (1S,2S)-[3-Chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester

IUPAC Name: tert-butyl N-[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate | CAS Registry Number: 165727-45-7
Synonyms: (1S,2S)-[3-Chloro-2-hydroxy-1-(phenylmethyl)-propyl]carbamic acid, 1,1-dimethylethyl ether, tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate, (1s, 2s)-(1-benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid tert-butyl ester, ZINC04242566, AC1OGCDY, PubChem11545, SureCN638912, (1S,2S)-(1-Benzyl-3-chloro-2-hydroxypropyl)carbamic acid tert-butyl ester, (1s,2s)-[3-chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester, MolPort-002-500-119, ANW-61140, SBB070951, AKOS015895861, AC-6536, AK-59927, S379, AB1004602, KB-259922, FT-0603927, I06-1305

Molecular Formula:	C₁₅H₂₂ClNO₃	Molecular Weight:	299.793080 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	3

InChIKey: GFGQSTIUFXHAJS-QWHCGFSZSA-N

• 3-Hydroxytetrahydrofuran

IUPAC Name: (3R)-oxolan-3-ol | CAS Registry Number: 453-20-3
Synonyms: Tetrahydrofuran-3-ol, 3-Furanol, tetrahydro-, 309753_ALDRICH, NSC71875, CID641512, ZINC04716349, (R)-(−)-3-Hydroxytetrahydrofuran, InChI=1/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H

Molecular Formula:	C₄H₈O₂	Molecular Weight:	88.105120 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	2

InChIKey: XDPCNPCKDGQBAN-SCSAIBSYSA-N

• 2-(4-Nitrophenyl)butyric acid

IUPAC Name: 2-(4-nitrophenyl)butanoic acid | CAS Registry Number: 7463-53-8
Synonyms: 2-(p-Nitrophenyl)butyric acid, EINECS 231-256-3, alpha-Ethyl-4-nitrobenzeneacetic acid, NSC 68215, NSC 404387, NSC23310, NSC68215, NSC404387, BUTYRIC ACID, 2-(p-NITROPHENYL)-, Benzeneacetic acid, alpha-ethyl-4-nitro-, LS-48129, ST5446656, Benzeneacetic acid, alpha-ethyl-4-nitro- (9CI), 46406-87-5

Molecular Formula:	C₁₀H₁₁NO₄	Molecular Weight:	209.198640 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	4

InChIKey: XBGNOMBPRQVJSR-UHFFFAOYSA-N

• (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone

IUPAC Name: tert-butyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate | CAS Registry Number: 102123-74-0
Synonyms: Boc-L-Phe chloromethyl ketone, (3S)-3-(TERT-BUTOXYCARBONYL)AMINO-1-CHLORO-4-PHENYL-2-BUTANONE, (3S)-3-(N-Boc-amino)-1-chloro-4-phenyl-2-butanone, (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate, PubChem11553, CTK4A0700, Carbamic acid,N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester, ANW-58959, AG-D-10494, RL00106, AK-55332, KB-75890, AB1004601, FT-0603935, Y6611, Carbamic acid,[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-,1,1-dimethylethyl ester, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-Carbamic acid 1,1-dimethylethyl ester, Carbamicacid, [(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester(9CI);Carbamic acid, [3-chloro-2-oxo-1-(phenylmethyl)propyl]-,1,1-dimethylethyl ester, (S)-;(3S)-(-)-3-tert-Butoxycarbonylamino-1-chloro-4-phenyl-2-butanone;(3S)-3-(tert-Butoxycarbonylamino)-1-chloro-4-phenyl-2-butanone;N-Boc phenylalanylchloride;

Molecular Formula:	C₁₅H₂₀ClNO₃	Molecular Weight:	297.777200 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: JAKDNFBATYIEIE-LBPRGKRZSA-N

• (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane

IUPAC Name: benzyl N-[1-(oxiran-2-yl)-2-phenylethyl]carbamate | CAS Registry Number: 128018-44-0
Synonyms: ACMC-20msov, ACMC-20mwnw, AGN-PC-002WZL, CTK0A9236, Carbamic acid,N-[(1S)-1-(2R)-2-oxiranyl-2-phenylethyl]-, phenylmethyl ester, Carbamic acid,N-[(1S)-1-[(2S)-2-oxiranyl]-2-phenylethyl]-, phenylmethyl ester, 137515-66-3, benzyl N-[(1S)-1-(oxiran-2-yl)-2-phenylethyl]carbamate, Carbamic acid, (1-oxiranyl-2-phenylethyl)-, phenylmethyl ester, 163915-59-1

Molecular Formula:	C₁₈H₁₉NO₃	Molecular Weight:	297.348360 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: DURMMNMFHRIMJD-UHFFFAOYSA-N