Profile: Biologichem, LLC offers fine chemicals. Tris(hydroxymethyl)aminomethane hydrochloride, commonly known as tris hydrochloride, has been primarily used for simplifying the process of preparing Tris buffer solutions. The use of solid Tris Hydrochloride avoids using more hazardous hydrochloric acid, and allows a more precise ratio to be measured to achieve a specific buffer pH. Tris(hydroxymethyl)aminomethane, commonly known as ?Tris? or ?Tris Base? has been used as a buffer in a wide variety of applications, including biological systems. Tris buffer solutions at a wide range of pH are generated using Tris Base and hydrochloric acid, or alternatively with Tris Base and Tris Hydrochloride in a defined ratio and concentration. The use of solid Tris Hydrochloride avoids using more hazardous hydrochloric acid, and allows a more precise ratio to be measured to achieve a specific buffer pH.