Alpha Chimica

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Contact: Bernardin Akagah
Web: http://www.alphachimica.com
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Address: Faculté de pharmacie, 5, rue Jean-Baptiste Clément, Tour D5, 5è étage, Châtenay-Malabry 92290, France
Phone: +33-(1)-46835696 | Fax: +33-(6)-46835972 | Map/Directions >>

Profile: Alpha Chimica specializes in the development of biomimetic catalysts, chemical entities, and drug candidates. We have created human Cytochrome P450 mimics for producing phase 1 metabolites in high yield. Among the advantages of our approach are rapid turnaround and high yield of prospective metabolites. Our biomimetic catalytic systems are based on metalloporphyrins, oxidant, co-oxidant and solvent medium. Our products include 2-naphthylmethoxyacetic acids, N-methylpyrrolidin-2-one hydrotribromide (MPHT), 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine, 7-hydroxy methotrexate, 2,3-oxidosqualene, 1,1',2-tris-nor-squalene aldehyde and 1,1',2-tris-nor-squalene acid. Our catalytic methods for synthetic transformation permit a rapid simulation of the results obtained using biological methods. We can produce multigram quantities of metabolites from the drug candidate.

12 Products/Chemicals (Click for related suppliers)

• Diethyl N-(4-Methylaminobenzoyl)-L-Glutamate

IUPAC Name: diethyl 2-[[4-(methylamino)benzoyl]amino]pentanedioate | CAS Registry Number: 2378-95-2
Synonyms: NSC121189, NSC121190, NSC255517, BAS 00238766, Diethyl N-(p-N-methylaminobenzoyl)glutamate, ST5000747, Diethyl N-[4-(methylamino)benzoyl]-L-glutamate, N-(p-Methylaminobenzoyl)glutamic acid diethyl ester, 2-(4-Methylamino-benzoylamino)-pentanedioic acid diethyl ester, Glutamic acid, N-[p-(methylamino)benzoyl]-, diethyl ester, L-, L-Glutamic acid, N-[4-(methylamino)benzoyl]-, diethyl ester, 51865-66-8

Molecular Formula:	C₁₇H₂₄N₂O₅	Molecular Weight:	336.382860 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	6

InChIKey: WBYNXAAEBPJETG-UHFFFAOYSA-N

• Fluorescein di-p-guanidinobenzoate (CAS: 83616-11-9)

• FLUORESCEIN DI-P-GUANIDINOBENZOATE HCL

IUPAC Name: [6'-[4-(diaminomethylideneamino)benzoyl]oxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 4-(diaminomethylideneamino)benzoate;hydrochloride | CAS Registry Number: 135367-80-5
Synonyms: F3636_SIGMA, Fluorescein di-(p-guanidinobenzoate) hydrochloride, FLUORESCEINDI-P-GUANIDINOBENZOATEHYDROCHLORIDE

Molecular Formula:	C₃₆H₂₇ClN₆O₇	Molecular Weight:	691.088580 [g/mol]
H-Bond Donor:	5	H-Bond Acceptor:	9

InChIKey: QTIBBLLJNPUURI-UHFFFAOYSA-N

• KEPONE ALCOHOL

Synonyms: CHLORDECONE ALCOHOL, Kepone alcohol, Reduced kepone, CHLORDECONE-ALCOHOL, CCRIS 6220, CHEBI:17184, CID13946, LS-371, AI3-24875, C02817, C029713, 1,3,4-Metheno-1H-cyclobuta(cd)pentalen-2-ol, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-1,3,4-Metheno-1H-cyclobuta(cd)pentalen-2-ol, CHLORDECONE ALCOHOL (SEE ALSO: CHLORDECONE (KEPONE) (CAS 143-50-0)), 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-1H-1,3,4-(methanetriyl)cyclobuta[cd]pentalen-2-ol, 1,2,3,4,6,7,8,9,10,10-decachloropentacyclo[5.3.0.0(2,6).0(3,9).0(4,8)]decan-5-ol, 1,3,4-Metheno-1H-cyclobuta[cd]pentalen-2-ol, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-

Molecular Formula:	C₁₀H₂Cl₁₀O	Molecular Weight:	492.652280 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	1

InChIKey: MBEIHNKADVMCJM-UHFFFAOYSA-N

• N-MethylPyrrolidin-2-one HydroTribromide (CAS: 12234-01-4)

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

IUPAC Name: 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine | CAS Registry Number: 28289-54-5
Synonyms: MPTP, CCRIS 2186, HSDB 6942, M1021_SIGMA, CHEBI:17963, EINECS 248-939-7, C12H15N, CID1388, NSC 139654, BRN 0133712, N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, NSC139654, STK191942, 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine, PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-, LS-132033, C04599, 5-20-07-00121 (Beilstein Handbook Reference), D015632

Molecular Formula:	C₁₂H₁₅N	Molecular Weight:	173.254200 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	1

InChIKey: PLRACCBDVIHHLZ-UHFFFAOYSA-N

• (6E,10E,14E,18E)-2,3-EPOXY-2,6,10,15,19,23-EPOXY-2,6,10,15,19,23-HEXAMETHYL-6,10,14,18,22-TETRACOSAPENTAENE

IUPAC Name: 2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,16,20-pentamethylhenicosa-3,7,11,15,19-pentaenyl]oxirane | CAS Registry Number: 7200-26-2
Synonyms: Squalene peroxide, 2,3-Oxidosqualene, Squalene-2,3-oxide, Squalene-2,3-epoxide, 2,3-Edsq, 2,3-Epoxy-2,3-dihydrosqualene, CID5366020, 2,2-Dimethyl-3-[(3E,7E,11E,15E)-3,7,12,16,20-pentamethyl-3,7,11,15,19-henicosapentaenyl]oxirane, Oxirane, 2,2-dimethyl-3-(3,7,12,16,20-pentamethyl-3,7,11,15,19-heneicosapentaenyl)-, (all-E)-, Oxirane, 2,2-dimethyl-3-(3,7,12,16,20-pentamethyl-3,7,11,15,19-heneicosapentaenyl)-, (all-E)- (VAN)

Molecular Formula:	C₃₀H₅₀O	Molecular Weight:	426.717400 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	1

InChIKey: QYIMSPSDBYKPPY-BANQPHDMSA-N

• (S)-alpha-Methoxy-2-Naphthylacetic Acid

IUPAC Name: (2S)-2-methoxy-2-naphthalen-2-ylacetic acid | CAS Registry Number: 157134-51-5
Synonyms: (S)-2-NMA, (S)-a-Methoxy-2-naphthylacetic acid, (S)--Methoxy-2-naphthylacetic acid, ZINC43763874, AKOS030532602, (S)-?-Methoxy-2-naphthaleneacetic acid, (S)-|A-Methoxy-2-naphthaleneacetic acid, (S)-alpha-Methoxy-2-naphthaleneacetic acid, DB-064159, (S)-alpha-Methoxy-2-naphthylacetic acid, 97%, (S)-2-NMA/ (S)-alp.-Methoxy-2-naphthaleneacetic acid

Molecular Formula:	C₁₃H₁₂O₃	Molecular Weight:	216.236 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: OQVFHDWREDKUCW-LBPRGKRZSA-N

• (R)-alpha-Methoxy-2-Naphthylacetic Acid

IUPAC Name: (2R)-2-methoxy-2-naphthalen-2-ylacetic acid | CAS Registry Number: 156942-67-5
Synonyms: (R)-2-NMA, CTK8E8553, (R)-|A-Methoxy-2-naphthylacetic acid, (R)-alpha-Methoxy-2-naphthylacetic acid, (R)-|A-Methoxy-2-naphthaleneacetic acid

Molecular Formula:	C₁₃H₁₂O₃	Molecular Weight:	216.232580 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: OQVFHDWREDKUCW-GFCCVEGCSA-N

• 3,4,5-TRIMETHOXY-BENZOIC ACID 2-(METHYLAMINO)-2-PHENYLBUTYL ESTER

IUPAC Name: [2-(methylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate | CAS Registry Number: 84333-59-5
Synonyms: N-Desmethyl-tmb, N-Desmethyltrimebutine, NDTMB, N-Monodemethyltrimebutine, MolPort-003-846-205, CID134748, Benzoic acid, 3,4,5-trimethoxy-, 2-(methylamino)-2-phenylbutyl ester

Molecular Formula:	C₂₁H₂₇NO₅	Molecular Weight:	373.442780 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	6

InChIKey: ZFPDLGDYDUPYEZ-UHFFFAOYSA-N

• 6H-INDOLO[3,2,1-DE][1,5]NAPHTHYRIDIN-6-ONE

Synonyms: Canthin-6-one, NCIOpen2_007333, MEGxp0_000046, ACon0_001416, CHEBI:355717, MolPort-000-165-436, AIDS228088, AIDS-228088, CID97176, NSC103003, ZINC00898052, NSC 103003, C09098, 6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one, 6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, NP-000090, Indolo[3,2,1-de][1,5]naphthyridin-6-one

Molecular Formula:	C₁₄H₈N₂O	Molecular Weight:	220.226120 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	2

InChIKey: ZERVJPYNQLONEK-UHFFFAOYSA-N

• 7-HYDROXY METHOXTREXATE

IUPAC Name: 2-[[4-[(2,4-diamino-7-oxo-8H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid | CAS Registry Number: 5939-37-7
Synonyms: 7-Hydroxymethotrexate, MolPort-003-847-896, NSC380962, AIDS007018, AIDS-007018, NSC380963, CID5385077, N-(4-(((2,4-Diamino-7-hydroxy-6-pteridinyl)methyl)(methyl)amino)benzoyl)glutamic acid, Glutamic acid, N-[p-[[(2,4-diamino-7-hydroxy- 6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-, L-Glutamic acid, N-[4-[[(2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-

Molecular Formula:	C₂₀H₂₂N₈O₆	Molecular Weight:	470.438680 [g/mol]
H-Bond Donor:	6	H-Bond Acceptor:	12

InChIKey: HODZDDDNGRLGSI-UHFFFAOYSA-N