Active Biochem

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Profile: Active Biochem offers inhibitors. Our products include 3-deazaneplanocin A, 5'-deoxy-5-fluorouridine, axitinib, artemether, and artemisinin. 3-Deazaneplanocin A (DZNep) is an S-sdenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

9 Products/Chemicals (Click for related suppliers)

• Cdk/Crk Inhibitor

IUPAC Name: 1-(2,6-dichlorophenyl)-6-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one | CAS Registry Number: 784211-09-2
Synonyms: RGB-286147, 1-(2,6-Dichlorophenyl)-1,5-dihydro-6-((4-(2-hydroxyethoxy)phenyl)methyl)-3-(1-methylethyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one, K00600a, SureCN1179657, CHEMBL258721, CTK8F1289, HMS3229E20, CCG-206832, NCGC00345809-01, Pyrazolopyrimidone analog, RGB-286147

Molecular Formula:	C₂₃H₂₂Cl₂N₄O₃	Molecular Weight:	473.351780 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	4

InChIKey: VQNCIRRXQQTXEL-UHFFFAOYSA-N

• Cdk1 Inhibitor

IUPAC Name: (3E)-3-[(2-chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one | CAS Registry Number: 220749-41-7
Synonyms: cdk1 inhibitor, CHEMBL261425, 3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one, AC1NV88J, GTPL5944, SCHEMBL1394886, HMS3229C12, HSCI1_000249, NSC720148, ZINC01662968, CCG-206822, NSC-720148, RT-011955, BRD-K81836716-001-01-7, (3E)-3-[(2-chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one, (3E)-3-[(2-chloro-1H-indol-3-yl)methylidene]-2,3-dihydro-1H-indol-2-one

Molecular Formula:	C₁₇H₁₁ClN₂O	Molecular Weight:	294.735040 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	1

InChIKey: QJKBRWSJWQVKLY-UKTHLTGXSA-N

• Cdk1/2 Inhibitor III

IUPAC Name: 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide | CAS Registry Number: 443798-55-8
Synonyms: 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, 2wu6, AC1NS9OB, CDK 1/2 INHIBITOR, CHEMBL261720, CTK8E9250, HMS3229C16, CCG-206824, DB07664, K00546, 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n, 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide, 5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1,2,4-triazole-1-carbothioamide

Molecular Formula:	C₁₅H₁₃F₂N₇O₂S₂	Molecular Weight:	425.436226 [g/mol]
H-Bond Donor:	4	H-Bond Acceptor:	10

InChIKey: ARIOBGGRZJITQX-UHFFFAOYSA-N

• Cdk2 Inhibitor II

IUPAC Name: 4-[2-(5-bromo-2-oxoindol-3-yl)hydrazinyl]benzenesulfonamide

Molecular Formula:	C₁₄H₁₁BrN₄O₃S	Molecular Weight:	395.231140 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	6

InChIKey: ODZNNZYRBRRREX-UHFFFAOYSA-N

• Eg5 Inhibitor IV, VS-83

IUPAC Name: 5-fluoro-4-(3-hydroxyphenyl)-3,4-dihydro-1H-quinazoline-2-thione | CAS Registry Number: 909250-29-9
Synonyms: 5-Fluoro-3,4-dihydro-4(3′-hydroxyphenyl)quinazoline-2(1H)-thione, AGN-PC-00AT3G, CTK8F1369, VS-83, 2(1H)-Quinazolinethione, 5-fluoro-3,4-dihydro-4-(3-hydroxyphenyl)-

Molecular Formula:	C₁₄H₁₁FN₂OS	Molecular Weight:	274.313343 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	3

InChIKey: MAEYCDNDKNPNQJ-UHFFFAOYSA-N

• ERK Inhibitor II, Negative Control

IUPAC Name: 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydropyrazolo[3,4-c]pyridazin-3-one | CAS Registry Number: 1177970-73-8
Synonyms: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, CHEMBL2218938, CTK8F0254, HMS3229G08, CCG-206838

Molecular Formula:	C₁₈H₁₂N₆O	Molecular Weight:	328.327480 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	5

InChIKey: QMBDONCHHMIWFJ-UHFFFAOYSA-N

• ERK Inhibitor III

IUPAC Name: 1-nitro-2-[(E)-[5-(3-nitrophenyl)furan-2-yl]methylideneamino]guanidine

Molecular Formula:	C₁₂H₁₀N₆O₅	Molecular Weight:	318.245000 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	7

InChIKey: RODAAYVFYDKHGT-VGOFMYFVSA-N

• Pyrazolylpyrrole ERK Inhibitor

IUPAC Name: N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1,2-dihydropyrazol-3-ylidene]pyrrole-2-carboxamide | CAS Registry Number: 933786-58-4
Synonyms: SureCN2729714, CTK8F1123

Molecular Formula:	C₂₂H₁₇Cl₂FN₄O₂	Molecular Weight:	459.300383 [g/mol]
H-Bond Donor:	4	H-Bond Acceptor:	6

InChIKey: ZOBKBFWGIGVEBC-UHFFFAOYSA-N

• 3-DEAZANEPLANOCIN

IUPAC Name: (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol | CAS Registry Number: 102052-95-9
Synonyms: c^Neplanocin A, DZNep, 3-Deazaneplanocin, 3-Deaza-neplanocin, 3-Deazaneplanocin A, 3-Deazaneplanocin-A, CHEBI:359998, AIDS032965, AIDS-032965, AVS-4275, CID73087, NSC617989 (HYDROCHLORIDE), (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine, (1S,2R,5R)-5-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-3-hydroxymethyl-cyclopent-3-ene-1,2-diol, 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo(4,5-c)pyridiny-1-yl)-3-(hydroxymethyl)-, (1S-(alpha,2alpha,5beta))-

Molecular Formula:	C₁₂H₁₄N₄O₃	Molecular Weight:	262.264560 [g/mol]
H-Bond Donor:	4	H-Bond Acceptor:	6

InChIKey: OMKHWTRUYNAGFG-IEBDPFPHSA-N