Profile: AM Chemicals is a supplier of solid supports and reagents for robust oligonucleotide synthesis. Our sulfurization agent DDTT, offers extremely high yields in the preparation of DNA and RNA phosphorothioates and affords excellent stability in solution. Our advanced universal phosphoramidite reagent eliminates the need of using nucleosidic solid supports. Regardless of the desired 3'-terminal nucleoside, most oligonucleotides can be synthesized starting with an OH- or NH2-functionalized solid support material by using the universal phosphoramidite in the first synthetic cycle. The unique design of our universal phosphoramidite ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.